Email: microbiomecore@healthcare.uiowa.edu
Location: 265 Medical Research Center (MRC)
Phone: 1-319-353-5470
 

Director

Ashutosh K. Mangalam, Ph.D.
106-B Medical Research Center (MRC)
Email: ashutosh-mangalam@uiowa.edu
Phone: (319) 335-8558

Research Professional

Leeann Aguilar, M.S.
265-A Medical Research Center (MRC)
Email: leeann-aguilar@uiowa.edu
Phone: (319) 353-5470

Recent Publications

Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls

Hoang, J., Gilbertson-White, S., Cady, N., Yadav, M., Shahi, S., Aguilar, L., Mangalam, A. K., & Cherwin, C. (2024). Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls. Biological research for nursing, 26(2), 219–230.

doi: 10.1177/10998004231205277

Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis

Lehman, P. C., Cady, N., Ghimire, S., Shahi, S. K., Shrode, R. L., Lehmler, H. J., & Mangalam, A. K. (2023). Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis. Environmental toxicology and pharmacology, 100, 104149.

doi: 10.1016/j.etap.2023.104149

Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria

Shrode, R. L., Knobbe, J. E., Cady, N., Yadav, M., Hoang, J., Cherwin, C., Curry, M., Garje, R., Vikas, P., Sugg, S., Phadke, S., Filardo, E., & Mangalam, A. K. (2023). Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria. Scientific reports, 13(1), 526.


doi: 10.1038/s41598-023-27436-3 

Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis

Shahi, S. K., Ghimire, S., Lehman, P. & Mangalam, A. K. (2022). Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis. Front Immunol 13 966417.

doi: 10.3389/fimmu.2022.966417.

Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness

Yadav, M., Ali, S., Shrode, R. L., Shahi, S. K., Jensen, S. N., Hoang, J., Cassidy, S., Olalde, H., Guseva, N., Paullus, M., Cherwin, C., Wang, K., Cho, T., Kamholz, J. & Mangalam, A. K. (2022). Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness. PloS One 17 (4) e0264556. 

doi: 10.1371/journal.pone.0264556.

Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation

Ghimire, S., Cady, N. M., Lehman, P., Peterson, S. R., Shahi, S. K., Rashid, F., Giri, S. & Mangalam, A. K. (2022). Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation. Gut Microbes 14 (1) 2127446.

doi: 10.1080/19490976.2022.2127446.

Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics

Shahi, S. K., Yadav, M., Ghimire, S., & Mangalam, A. K. (2022). Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics. International review of neurobiology, 167, 185–215. 

doi: 10.1016/j.celrep.2021.110170.

The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice

Simonsen, D., Cady, N., Zhang, C., Shrode, R. L., McCormick, M. L., Spitz, D. R., Chimenti, M. S., Wang, K., Mangalam, A., & Lehmler, H. J. (2022). The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicological sciences : an official journal of the Society of Toxicology, 186(1), 102–117.

doi: 10.1093/toxsci/kfab142 

Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease

Aggarwal, N., Deerhake, M. E., DiPalma, D., Shahi, S. K., Gaggioli, M. R., Mangalam, A. K., & Shinohara, M. L. (2021). Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. Cell reports, 37(13), 110170. 

doi: 10.1016/j.celrep.2021.110170

Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer

Chau, J., Yadav, M., Liu, B., Furqan, M., Dai, Q., Shahi, S., Gupta, A., Mercer, K. N., Eastman, E., Hejleh, T. A., Chan, C., Weiner, G. J., Cherwin, C., Lee, S. T. M., Zhong, C., Mangalam, A., & Zhang, J. (2021). Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer. BMC cancer, 21(1), 808.

doi: https://doi.org/10.1186/s12885-021-08530-z 

More Publications

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Shahi, S. K., Zarei, K., Guseva, N. V., & Mangalam, A. K. (2019). Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing. Journal of visualized experiments : JoVE, (152), 10.3791/59980. https://doi.org/10.3791/59980

Fungal microbiome and multiple sclerosis: The not-so-new kid on the block.

Mangalam A. K. (2021). Fungal microbiome and multiple sclerosis: The not-so-new kid on the block. EBioMedicine, 72, 103621. 

https://doi.org/10.1016/j.ebiom.2021.103621

The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges

Mangalam, A. K., Yadav, M., & Yadav, R. (2021). The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges. Indian journal of rheumatology, 16(1), 57–72. https://doi.org/10.4103/injr.injr_210_20

Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects

Abu El Haija, M., Ye, Y., Chu, Y., Herz, H., Linden, B., Shahi, S. K., Zarei, K., Mangalam, A. K., Mcelroy, S. J., & Mokadem, M. (2021). Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 17(12), 1996–2006. 
https://doi.org/10.1016/j.soard.2021.07.019

HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype

Shahi, S. K., Ali, S., Jaime, C. M., Guseva, N. V., & Mangalam, A. K. (2021). HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype. ImmunoHorizons, 5(8), 627–646. 

https://doi.org/10.4049/immunohorizons.2100024

Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis

Jensen, S. N., Cady, N. M., Shahi, S. K., Peterson, S. R., Gupta, A., Gibson-Corley, K. N., & Mangalam, A. K. (2021). Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Science advances, 7(28), eabd4595. 

https://doi.org/10.1126/sciadv.abd4595

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

Ye, Y., Abu El Haija, M., Morgan, D. A., Guo, D., Song, Y., Frank, A., Tian, L., Riedl, R. A., Burnett, C. M. L., Gao, Z., Zhu, Z., Shahi, S. K., Zarei, K., Couvelard, A., Poté, N., Ribeiro-Parenti, L., Bado, A., Noureddine, L., Bellizzi, A., Kievit, P., … Mokadem, M. (2020). Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell reports, 33(4), 108270. 

https://doi.org/10.1016/j.celrep.2020.108270

Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis

A., & Mangalam, A. K. (2020). Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 11, 578648. https://doi.org/10.3389/fimmu.2020.578648