Location: 265 Medical Research Center (MRC)
Phone: 1-319-353-5470


Ashutosh K. Mangalam, Ph.D.
106-B Medical Research Center (MRC)
Phone: (319) 335-8558

Research Professional

Leeann Aguilar, M.S.
265-A Medical Research Center (MRC)
Phone: (319) 353-5470

Recent Publications

Hoang, J., Gilbertson-White, S., Cady, N., Yadav, M., Shahi, S., Aguilar, L., Mangalam, A. K., & Cherwin, C. (2024). Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls. Biological research for nursing, 26(2), 219–230.

doi: 10.1177/10998004231205277

Lehman, P. C., Cady, N., Ghimire, S., Shahi, S. K., Shrode, R. L., Lehmler, H. J., & Mangalam, A. K. (2023). Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis. Environmental toxicology and pharmacology, 100, 104149.

doi: 10.1016/j.etap.2023.104149

Shrode, R. L., Knobbe, J. E., Cady, N., Yadav, M., Hoang, J., Cherwin, C., Curry, M., Garje, R., Vikas, P., Sugg, S., Phadke, S., Filardo, E., & Mangalam, A. K. (2023). Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria. Scientific reports, 13(1), 526.

doi: 10.1038/s41598-023-27436-3 

Shahi, S. K., Ghimire, S., Lehman, P. & Mangalam, A. K. (2022). Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis. Front Immunol 13 966417.

doi: 10.3389/fimmu.2022.966417.

Yadav, M., Ali, S., Shrode, R. L., Shahi, S. K., Jensen, S. N., Hoang, J., Cassidy, S., Olalde, H., Guseva, N., Paullus, M., Cherwin, C., Wang, K., Cho, T., Kamholz, J. & Mangalam, A. K. (2022). Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness. PloS One 17 (4) e0264556. 

doi: 10.1371/journal.pone.0264556.

Ghimire, S., Cady, N. M., Lehman, P., Peterson, S. R., Shahi, S. K., Rashid, F., Giri, S. & Mangalam, A. K. (2022). Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation. Gut Microbes 14 (1) 2127446.

doi: 10.1080/19490976.2022.2127446.

Shahi, S. K., Yadav, M., Ghimire, S., & Mangalam, A. K. (2022). Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics. International review of neurobiology, 167, 185–215. 

doi: 10.1016/j.celrep.2021.110170.

Simonsen, D., Cady, N., Zhang, C., Shrode, R. L., McCormick, M. L., Spitz, D. R., Chimenti, M. S., Wang, K., Mangalam, A., & Lehmler, H. J. (2022). The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicological sciences : an official journal of the Society of Toxicology, 186(1), 102–117.

doi: 10.1093/toxsci/kfab142 

Aggarwal, N., Deerhake, M. E., DiPalma, D., Shahi, S. K., Gaggioli, M. R., Mangalam, A. K., & Shinohara, M. L. (2021). Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. Cell reports, 37(13), 110170. 

doi: 10.1016/j.celrep.2021.110170

Chau, J., Yadav, M., Liu, B., Furqan, M., Dai, Q., Shahi, S., Gupta, A., Mercer, K. N., Eastman, E., Hejleh, T. A., Chan, C., Weiner, G. J., Cherwin, C., Lee, S. T. M., Zhong, C., Mangalam, A., & Zhang, J. (2021). Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer. BMC cancer, 21(1), 808.


More Publications

Shahi, S. K., Zarei, K., Guseva, N. V., & Mangalam, A. K. (2019). Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing. Journal of visualized experiments : JoVE, (152), 10.3791/59980.

Mangalam A. K. (2021). Fungal microbiome and multiple sclerosis: The not-so-new kid on the block. EBioMedicine, 72, 103621.

Mangalam, A. K., Yadav, M., & Yadav, R. (2021). The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges. Indian journal of rheumatology, 16(1), 57–72.

Abu El Haija, M., Ye, Y., Chu, Y., Herz, H., Linden, B., Shahi, S. K., Zarei, K., Mangalam, A. K., Mcelroy, S. J., & Mokadem, M. (2021). Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 17(12), 1996–2006.

Shahi, S. K., Ali, S., Jaime, C. M., Guseva, N. V., & Mangalam, A. K. (2021). HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype. ImmunoHorizons, 5(8), 627–646.

Jensen, S. N., Cady, N. M., Shahi, S. K., Peterson, S. R., Gupta, A., Gibson-Corley, K. N., & Mangalam, A. K. (2021). Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Science advances, 7(28), eabd4595.

Ye, Y., Abu El Haija, M., Morgan, D. A., Guo, D., Song, Y., Frank, A., Tian, L., Riedl, R. A., Burnett, C. M. L., Gao, Z., Zhu, Z., Shahi, S. K., Zarei, K., Couvelard, A., Poté, N., Ribeiro-Parenti, L., Bado, A., Noureddine, L., Bellizzi, A., Kievit, P., … Mokadem, M. (2020). Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell reports, 33(4), 108270.

A., & Mangalam, A. K. (2020). Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 11, 578648.