Email: microbiomecore@healthcare.uiowa.edu
Location: 265 Medical Research Center (MRC)
Phone: 1-319-353-5470
Director
Ashutosh K. Mangalam, Ph.D.
106-B Medical Research Center (MRC)
Email: ashutosh-mangalam@uiowa.edu
Phone: (319) 335-8558
Research Professional
Leeann Aguilar, M.S.
265-A Medical Research Center (MRC)
Email: leeann-aguilar@uiowa.edu
Phone: (319) 353-5470
Recent Publications
Hoang, J., Gilbertson-White, S., Cady, N., Yadav, M., Shahi, S., Aguilar, L., Mangalam, A. K., & Cherwin, C. (2024). Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls. Biological research for nursing, 26(2), 219–230.
Lehman, P. C., Cady, N., Ghimire, S., Shahi, S. K., Shrode, R. L., Lehmler, H. J., & Mangalam, A. K. (2023). Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis. Environmental toxicology and pharmacology, 100, 104149.
Shrode, R. L., Knobbe, J. E., Cady, N., Yadav, M., Hoang, J., Cherwin, C., Curry, M., Garje, R., Vikas, P., Sugg, S., Phadke, S., Filardo, E., & Mangalam, A. K. (2023). Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria. Scientific reports, 13(1), 526.
Shahi, S. K., Ghimire, S., Lehman, P. & Mangalam, A. K. (2022). Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis. Front Immunol 13 966417.
Yadav, M., Ali, S., Shrode, R. L., Shahi, S. K., Jensen, S. N., Hoang, J., Cassidy, S., Olalde, H., Guseva, N., Paullus, M., Cherwin, C., Wang, K., Cho, T., Kamholz, J. & Mangalam, A. K. (2022). Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness. PloS One 17 (4) e0264556.
Ghimire, S., Cady, N. M., Lehman, P., Peterson, S. R., Shahi, S. K., Rashid, F., Giri, S. & Mangalam, A. K. (2022). Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation. Gut Microbes 14 (1) 2127446.
Shahi, S. K., Yadav, M., Ghimire, S., & Mangalam, A. K. (2022). Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics. International review of neurobiology, 167, 185–215.
Simonsen, D., Cady, N., Zhang, C., Shrode, R. L., McCormick, M. L., Spitz, D. R., Chimenti, M. S., Wang, K., Mangalam, A., & Lehmler, H. J. (2022). The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicological sciences : an official journal of the Society of Toxicology, 186(1), 102–117.
Aggarwal, N., Deerhake, M. E., DiPalma, D., Shahi, S. K., Gaggioli, M. R., Mangalam, A. K., & Shinohara, M. L. (2021). Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. Cell reports, 37(13), 110170.
Chau, J., Yadav, M., Liu, B., Furqan, M., Dai, Q., Shahi, S., Gupta, A., Mercer, K. N., Eastman, E., Hejleh, T. A., Chan, C., Weiner, G. J., Cherwin, C., Lee, S. T. M., Zhong, C., Mangalam, A., & Zhang, J. (2021). Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer. BMC cancer, 21(1), 808.
More Publications
Shahi, S. K., Zarei, K., Guseva, N. V., & Mangalam, A. K. (2019). Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing. Journal of visualized experiments : JoVE, (152), 10.3791/59980. https://doi.org/10.3791/59980
Mangalam A. K. (2021). Fungal microbiome and multiple sclerosis: The not-so-new kid on the block. EBioMedicine, 72, 103621.
https://doi.org/10.1016/j.ebiom.2021.103621
Mangalam, A. K., Yadav, M., & Yadav, R. (2021). The Emerging World of Microbiome in Autoimmune Disorders: Opportunities and Challenges. Indian journal of rheumatology, 16(1), 57–72. https://doi.org/10.4103/injr.injr_210_20
Shahi, S. K., Ali, S., Jaime, C. M., Guseva, N. V., & Mangalam, A. K. (2021). HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype. ImmunoHorizons, 5(8), 627–646.
https://doi.org/10.4049/immunohorizons.2100024
Jensen, S. N., Cady, N. M., Shahi, S. K., Peterson, S. R., Gupta, A., Gibson-Corley, K. N., & Mangalam, A. K. (2021). Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Science advances, 7(28), eabd4595.
https://doi.org/10.1126/sciadv.abd4595
Ye, Y., Abu El Haija, M., Morgan, D. A., Guo, D., Song, Y., Frank, A., Tian, L., Riedl, R. A., Burnett, C. M. L., Gao, Z., Zhu, Z., Shahi, S. K., Zarei, K., Couvelard, A., Poté, N., Ribeiro-Parenti, L., Bado, A., Noureddine, L., Bellizzi, A., Kievit, P., … Mokadem, M. (2020). Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell reports, 33(4), 108270.
https://doi.org/10.1016/j.celrep.2020.108270
A., & Mangalam, A. K. (2020). Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 11, 578648. https://doi.org/10.3389/fimmu.2020.578648